I'm setting it up with the frequency spread such that it is (as I understand it) an octature LFO (0, 45, 90, 135, 180, etc) or simply using it to do polyrhythmic modulation on one instrument (4 bar filter sweep, 3/4 bar PWM modulation, 2/5 bar modulation of an envelope decay via a combinator etc).
Things like the Noise Engineering RE's that are rather boring without external modulation come alive when using multiple LFO's from CV Pistons.