as a guitarist, it makes me sad to hear people trying to make synths sound like guitars. I’ve yet to hear a synth “guitar” that sounds even remotely close. they’re not even pale imitations most of the time. the fact that they’re trying to make it sound like a guitar is very obvious, making the failure to do so even more so.
that said, there’s one guy here on RS who does a really good job of it (Tritoneaddiction, I believe)—still sounds like a synth, but I think it works because it doesn’t seem like there’s an expectation for it to sound precisely like a guitar. the focus is on making it sound great in a song/mix instead of making it sound like a guitar. it doesn’t hurt that the songs themselves are really good.
using a guitar sampled instrument, like the OP is asking for makes more sense, but I can’t imagine the amount of tweaking it would take to make it believable as a focal point of a song.
okay, old guy rant, over.