I've been using more and more third-party plugins and recently noticed on my vocal tracks that automations don't respond properly. This is also the case with anything related to time, such as Synchronous, PanMan, LFO Tool etc. It's generally not noticeable when it's just a few samples delay, but when you start stacking plugins with lots of look-ahead, it suddenly becomes very apparent. What's scary is that even the mix channel's volume fader is affected. Basically anything that comes after "heavy" plugins will be timed wrong; I tried automating the gain using kHs Gain put last in the chain but that didn't respond correctly in the sequencer either.
Delay compensation is complex and most DAWs have some strange things going on, but I feel like you should at least expect individual channels--there's no interaction between tracks with various delays--to work. When I can't even draw sidechain on my own and expect it to be in time, something's not right.
Example #1 (automating mute):
Example #2 (LFO/envelope with Synchronous):